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Cycloheximide

PESTANAL®, analytical standard

Synonym: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A

  • CAS Number 66-81-9

  • Empirical Formula (Hill Notation) C15H23NO4

  • Molecular Weight 281.35

  •  Beilstein/REAXYS Number 88868

  •  EC Number 200-636-0

  •  MDL number MFCD00082346

  •  PubChem Substance ID 329757163

  •  NACRES NA.24

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Properties

Related Categories Alpha Index of All Pesticide Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z,
Quality Level   100
grade   analytical standard
description   mixture of stereo isomers
product line   PESTANAL®
assay   ≥95% (HPLC)
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
solubility   H2O: slightly soluble
Featured Industry   Agriculture
Cleaning Products
Cosmetics
Environmental
Food and Beverages
Personal Care
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   fungi
format   neat
storage temp.   −20°C
SMILES string   [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
InChI   1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key   YPHMISFOHDHNIV-FSZOTQKASA-N

Description

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Legal Information

PESTANAL is a registered trademark of Sigma-Aldrich International GmbH

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
WGK 3
RTECS 
MA4375000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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