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Praziquantel

VETRANAL, analytical standard

Synonym: 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

  • CAS Number 55268-74-1

  • Empirical Formula (Hill Notation) C19H24N2O2

  • Molecular Weight 312.41

  •  Beilstein/REAXYS Number 761557

  •  EC Number 259-559-6

  •  MDL number MFCD00058531

  •  PubChem Substance ID 329756613

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z,
Quality Level   200
grade   analytical standard
InChI Key   FSVJFNAIGNNGKK-UHFFFAOYSA-N
product line   VETRANAL
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
Mode of action   cell membrane | interferes
antibiotic activity spectrum   parasites
format   neat
storage temp.   2-8°C

Description

General description

Chemical structure: quinolone

Praziquantel (PZQ) is a pyrazino-isoquinoline compound used as a broad-spectrum anthelmintic drug against trematode and cestode infections.

Application

PZQ may be used as a reference standard for the determination for PZQ in:
• Surface water samples by solid phase extraction (SPE) and ultra-high performance liquid chromatography-quadrupole linear ion trap tandem mass spectrometry (UHPLC-QqLIT-MS) equipped with electrospray ionization (ESI) source.
• Plants by HPLC with triple quadrupole mass spectrometry (HPLC-ESI-QqQ-MS/MS) operating in multiple reaction monitoring (MRM) mode.
• Tablet formulations by reversed phase (RP) HPLC with ultraviolet (UV) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
UQ4150000

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Praziquantel Determination in Aquarium Water by Direct Injection of Samples Using a Monolithic Silica Column

Praziquantel (PZQ) is used in the aquarium industry to treat monogenea and other parasites. This is often done through a bath immersion treatment, where medications are dissolved in aquarium water ra...
Bruce Herzig and Kailen Gilde
Keywords: Chromatography, Eliminations, Filtration, High performance liquid chromatography, Reductions, Sample preparations, Separation, Solid phase extractions, Solvents

Peer-Reviewed Papers
15

References

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