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Prednisolone

VETRANAL®, analytical standard

Synonym: 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrohydrocortisone, 1-Dehydrocortisol, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione

  • CAS Number 50-24-8

  • Empirical Formula (Hill Notation) C21H28O5

  • Molecular Weight 360.44

  •  Beilstein/REAXYS Number 1354103

  •  EC Number 200-021-7

  •  MDL number MFCD00003649

  •  PubChem Substance ID 329756614

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, All Doping Standards (A-Z), Analytical Standards, Analytical/Chromatography, Application Areas and Market Segments,
Quality Level   100
grade   analytical standard
product line   VETRANAL®
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   240 °C (dec.) (lit.)
Featured Industry   Forensics and Toxicology
Pharmaceutical (small molecule)
format   neat
SMILES string   O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
InChI   1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key   OIGNJSKKLXVSLS-VWUMJDOOSA-N
Gene Information   human ... NR3C1(2908)

Description

General description

Prednisolone is classified under the corticosteroids class of compounds.

Application

Prednisolone may be used as an analytical standard for the determination of prednisolone in:
• Human plasma by multivariate curve resolution-alternating least squares (MCR-ALS) technique combined with high performance liquid chromatography-diode array detection (HPLC-DAD).
• Urine, blood and food matrices by solid-phase extraction (SPE) and LC coupled to tandem mass spectrometry (LC-MS/MS).
• Surface water samples by SPE and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF) with electrospray ionization (ESI).
• Bovine muscle samples by ESI-LC-MS/MS equipped with multiple reaction monitoring (MRM) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
TU4152000

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

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Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

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From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Steroids on Ascentis® Express F5
Keywords: Separation

UHPLC/MS Analysis of Steroids on Titan™ C18

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Keywords: Chromatography, Mass spectrometry, Pharmaceutical

Peer-Reviewed Papers
15

References

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