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Neotame

analytical standard

Synonym: N-[N-(3,3-Dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester

  • CAS Number 165450-17-9

  • Empirical Formula (Hill Notation) C20H30N2O5

  • Molecular Weight 378.46

  •  Beilstein/REAXYS Number 8352678

  •  MDL number MFCD09039056

  •  PubChem Substance ID 329757524

  •  E Number E961

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Application Areas and Market Segments, E numbers (Food Additives),
Quality Level   100
grade   analytical standard
assay   ≥98.0% (HPLC)
form   neat
optical activity   [α]/D -41.0±3.0°, c = 0.5 in H2O
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Cleaning Products
Cosmetics
Food and Beverages
Personal Care
format   neat
SMILES string   COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NCCC(C)(C)C
InChI   1S/C20H30N2O5/c1-20(2,3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9,15-16,21H,10-13H2,1-4H3,(H,22,25)(H,23,24)/t15-,16-/m0/s1
InChI key   HLIAVLHNDJUHFG-HOTGVXAUSA-N

Description

General description

Neotame is a white colored, dipeptide methyl ester, which is found to be a highly potent and non-nutritive sweetener or flavour enhancer and hence finds applications in variety of foods. It is manufactured from aspartame and 3,3-dimethylbutyraldehyde in a one-step chemical synthesis process.

Neotame is chemically related to aspartame, an artificial sweetener, used in the production of sugar-free low-calorie foodstuffs. It is approved as a food additive depending upon the food or beverage application.

Application

Neotame may be used as an analytical reference standard for the quantification of the analyte in the following:
• Wine samples using reversed-phase high-performance liquid chromatography (RP-HPLC).
• Wastewaters using hydrophilic interaction liquid chromatography (HILIC).
• Food samples using high-performance liquid chromatography (HPLC).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Determination of Additives in Beverages Using Ascentis Express Columns

Beverages, such as sodas and energy drinks, can contain a number of polar ingredients, which are easily soluble in the water matrix of the drinks. These ingredients include sweeteners (sugars and sug...
Olga Shimelis, Hugh Cramer, and Michael D. Buchanan
US Reporter Volume 30.3
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Sample preparations, Separation, Vitamins

HPLC Analysis of Diet Soda Additives on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Diet Soda Additives on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Separation

HPLC Analysis of Diet Soda Additives on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Diet Soda Additives on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Separation

HPLC Analysis of Diet Soda Spiked with Neotame on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Diet Soda Spiked with Neotame on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Separation

HPLC Analysis of Diet Soda Spiked with Neotame on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Diet Soda Spiked with Neotame on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Separation

Peer-Reviewed Papers
15

References

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