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56396 Supelco

Caffeine

certified reference material, TraceCERT®

Synonym: 1,3,7-Trimethylxanthine

  • CAS Number 58-08-2

  • Empirical Formula (Hill Notation) C8H10N4O2

  • Molecular Weight 194.19

  •  Beilstein Registry Number 17705

  •  EC Number 200-362-1

  •  MDL number MFCD00005758

  •  PubChem Substance ID 329758206

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Description

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

General description

Caffeine is a behaviorally active substance mainly found in beverages like coffee and tea. It can have diverse effects on brain functions.

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034 (ISO Guide 34). This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Legal Information

TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
EV6475000

Documents

Certificate of Analysis

Protocols & Articles

Articles

Characterization of Stable Isotope Caffeine as Reference Material for Isotope Dilution Mass Spectrometry

Introduction Isotope Dilution Mass Spectrometry (IDMS) is a very precise method to determine concentrations of a given analyte in pure materials or in any type of matrix. This technique is based on t...
Rudolf Köhling, Christine Hellriegel
Analytix Volume 2, 2015
Keywords: Chromatography, Clinical, Clinical Chemistry, High performance liquid chromatography, Mass spectrometry, Nuclear magnetic resonance spectroscopy, Phase transitions, Titrations

Detection and Determination of Caffeine, Taurine and Arginine in Shampoos by HPTLC

During the last few years a new trend in hair care products (shampoos) has become apparent. The cleaning ability of the product is no longer the primary focus as the cosmetic industry has started to ...
Keywords: Adsorption, Chromatography, Cosmetics, Derivatizations, Mass spectrometry, Nuclear magnetic resonance spectroscopy, Separation, Thin layer chromatography

Determination of Additives in Beverages Using Ascentis Express Columns

Beverages, such as sodas and energy drinks, can contain a number of polar ingredients, which are easily soluble in the water matrix of the drinks. These ingredients include sweeteners (sugars and sug...
Olga Shimelis, Hugh Cramer, and Michael D. Buchanan
US Reporter Volume 30.3
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Sample preparations, Separation, Vitamins

HPLC Analysis of Maté Leaves on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Maté Leaves on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Sample preparations, Vitamins

TLC Analysis of Ingredients in Analgesic Agents on HPTLC pre-coated Plate 60 RP-18 WF 254s with concentrating zone

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Ingredients in Analgesic Agents on HPTLC pre-coated Plate 60 RP-18 WF 254s with concentrating zone
Keywords: Thin layer chromatography

Related Content

Flavor and Fragrance Analysis

We offer quality product solutions in all three stages of analysis to help achieve fast, accurate results. Below, you can learn more about our workflow solutions for sample preparation, separation, d...
Keywords: Calorimetry, Chromatography, Environmental, Gas chromatography, Mass spectrometry, Pesticides, Sample preparations, Separation

Peer-Reviewed Papers
15

References

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