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56480 Sigma-Aldrich

N-Hydroxysuccinimide

purum, ≥97.0% (T)

Synonym: 1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS

  • CAS Number 6066-82-6

  • Empirical Formula (Hill Notation) C4H5NO3

  • Molecular Weight 115.09

  •  Beilstein/REAXYS Number 113913

  •  EC Number 228-001-3

  •  MDL number MFCD00005516

  •  PubChem Substance ID 329758217

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Properties

Related Categories Active Esters/Additives, Chemical Biology, Chemical Synthesis, Coupling, Peptide Coupling,
InChI Key   NQTADLQHYWFPDB-UHFFFAOYSA-N
grade   purum
assay   ≥97.0% (T)
mp   95-98 °C (lit.)
  95-98 °C

Description

Application

N-Hydroxysuccinimide (NHS) can be used in the following applications:
• To synthesize N-succinimidyl 3-(2-pyridyldithio)-propionate, a heterobifunctional reagent useful for protein-protein conjugation and also to incorporate aliphatic thiols into proteins.
• To synthesize NHS esters of long-chain fatty acids.
• NHS can activate the phosphonic acid monolayers immobilized on titanium surface for binding with proteins.

Packaging

1 kg in poly bottle

25, 100 g in poly bottle

Other Notes

may contain 1-3% succinic acid and/or succinic anhydride

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Coupling Reagents

In principle, the seemingly simple formation of a peptide bond can be accomplished using all the procedures available in organic chemistry for the synthesis of carboxylic acid amides. However, due to...
Matthias Junkers
Aldrich ChemFiles 2007, 7.2, 3.
Keywords: Acylations, Catalysis, Condensations, Dehydration reaction, Peptide synthesis, Racemizations, Solid phase peptide synthesis

Desalting of Immunoglobulins (IgG, Human) on HiTrap® Desalting Cartridge

From our library of Articles, Sigma-Aldrich presents Desalting of Immunoglobulins (IgG, Human) on HiTrap® Desalting Cartridge
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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