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574732 Sigma-Aldrich

Acetonitrile solution

contains 0.1 % (v/v) trifluoroacetic acid, for HPLC




18 L in VerSA-Flow™

20 L in Nowpak™

4, 4×4 L in glass bottle

View returnable container options.

200 L in Pure-Pac™ 1

Preparation Note

Product filtered through a 0.2 μm filter

General description

The product is an acetonitrile solution containing 0.1%v/v trifluoroacetic acid. This pre-blended mobile phase solvent is of high purity that reduces time-consuming preparation and prevents instrument downtime because of impure mobile phases. Trifluoroacetic acid/acetonitrile mobile phase system is generally employed for peptide separation. Acetonitrile (MeCN), an organic solvent has low viscosity, high elution strength and is UV transparent at low wavelength. Trifluoroacetic acid (TFA) is commonly used as a mobile phase additive. It is a volatile acid that forms hydrophobic negatively charged trifluoroacetate ion.

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Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
UN 1648 3 / PGII
WGK Germany 
Flash Point(F) 
42.8 °F
Flash Point(C) 
6 °C


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

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Properties of Solvents Table

a. Gant, R., LC/GC 10 (7), 515 (1992) 1. At 20 °C 2. At 20 °C +/- 5 °C relative to water at 4 °C 3. At 10 mmHg pressure 4. At l=589.32 nm
Keywords: Gas chromatography, High performance liquid chromatography

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