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59924 Sigma-Aldrich

Polysorbate 80

tested according to Ph Eur

Synonym: POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80, Polysorbatum 80, TWEEN® 80

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Properties

Agency/Method   tested according to Ph Eur
Quality Level   200
vapor pressure   <1 mmHg ( 20 °C)
description   non-ionic
mol wt   average mol wt 79,000
aggregation number   60
refractive index   n20/D 1.472 (lit.)
CMC   0.012
transition temp   cloud point 65 °C
density   1.064 g/mL at 25 °C (lit.)
HLB   15
Featured Industry   Pharmaceutical (small molecule)
InChI   1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
InChI key   RGPBUVUVZKQNHD-MDZDMXLPSA-N

Description

General description

Polysorbate 80 is a surfactant. Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains.

Application

Polysorbate 80 has been used in drug (rapamycin) treatment and to study the effect of rapamycin on osteolysis and tumor growth. It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy.

Biochem/physiol Actions

Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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