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61188 Sigma-Aldrich

Losartan potassium

analytical standard

Synonym: 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt

  • CAS Number 124750-99-8

  • Empirical Formula (Hill Notation) C22H22ClKN6O

  • Molecular Weight 461.00

  •  Beilstein Registry Number 5845770

  •  MDL number MFCD02092704

  •  PubChem Substance ID 329759382

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Cardiac Drug Standards, Chromatography,
grade   analytical standard
InChI Key   OXCMYAYHXIHQOA-UHFFFAOYSA-N
form   powder or crystals
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
impurities   ≤0.5% water
format   neat

Description

Packaging

100 mg in glass bottle

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What class of compound is Losartan Potassium, Product 61188?
Losartan is an angiotensin II receptor antagonist that is used to treat hypertension.It has imidazole, tetrazole, and benzene rings as part of its structure. It is anionic at neutral pH; it has a pKa in the range of 4-5.
What HPLC column can I use for the analysis of Losartan in my samples?
Losartan is commonly analyzed using a C18 RP-HPLC column.Here at Supelco, we have successfully separated Valsartan, Losartan, and Irbesartan by HPLC chromatography on an Ascentis Express C18 15cm x 3mm column , using a mobile phase of 45:55, water:(0.1% formic acid in acetonitrile).Run times were less than 3 minutes, with the flow rate set at 0.4 mL/min (35° C).
What do you suggest for sample preparation?
For extraction from biological fluids, consider HybridSPE - precipitation
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
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Protocols & Articles

Articles

UHPLC Analysis of Losartan and Quinapril on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Losartan and Quinapril on Titan™ C18
Keywords: Chromatography, Mass spectrometry, Pharmaceutical

UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical, Separation

Peer-Reviewed Papers
15

References

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