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  • 675970 - Cyclopentyl methyl ether

675970 Sigma-Aldrich

Cyclopentyl methyl ether Green Alternative

contains 50 ppm BHT as inhibitor, anhydrous, ≥99.9%

Synonym: CPME

  • CAS Number 5614-37-9

  • Empirical Formula (Hill Notation) C6H12O

  • Molecular Weight 100.16

  •  MDL number MFCD08276401

  •  PubChem Substance ID 57652096



Related Categories Anhydrous Solvents, Greener Solvent Alternatives, Solvent by Type, Solvent Bottles, Solvent Packaging Options,
grade   anhydrous
assay   ≥99.9%
contains   50 ppm BHT as inhibitor
greener alternative product characteristics   Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.
impurities   ≤0.0050% H2O
  ≤0.0050% water
  ≤50 ppm H2O2
evapn. residue   <0.003%
bp   106 °C/760 mmHg
mp   -140 °C (lit.)
density   0.86 g/mL at 25 °C


Features and Benefits

Greener alternative for THF, Diethyl ether, and MTBE


1, 2 L in Sure/Seal™

100, 12×100 mL in Sure/Seal™


• Cyclopentyl methyl ether (CPME) is an alternative to ether solvents such as THF, diethyl ether, and MTBE with a higher resistance to peroxide formation.
• The more environmentally conservative CPME solvent replaces hazardous solvents in order to achieve sustainability and reduce environmental and operational costs.
• CPME offers considerable potential and advantage as a direct replacement for CH2Cl2 in binary eluents using MeOH as the modifier with MeOH–DMC and i-PrOH–EtOAc.

Green Alternative to THF, tert-Butyl methyl ether (MTBE), 1,4 Dioxane and other ether solvents

The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent.

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
UN 3271 3 / PGII
WGK Germany 
Flash Point(F) 
30.2 °F
Flash Point(C) 
-1 °C

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
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The lot specific COA document can be found by entering the lot number above under the "Documents" section.
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Protocols & Articles


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*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Stereospecific Cross-Coupling of Secondary Organotrifluoroborates: Potassium 1-(Benzyloxy)alkyltrifluoroborates

The synthesis of potassium trifluoro(N-methylheteroaryl)borates and their use in cross-coupling reactions with various aryl and heteroaryl halides to construct N-methyl heteroaryl-substituted aromati...
Keywords: Chromatography, Column chromatography, Coupling reactions, Cross couplings

Suzuki-Miyaura Cross-Coupling of Potassium Trifluoro(N-methylheteroaryl)borates with Aryl and Heteroaryl Halides

A new bulky biarylphosphine ligand (L8) has been developed that allows the Pd-catalyzed C-O cross-coupling of a wide range of aryl halides and phenols under milder conditions than previously possible...
Keywords: Catalysis, Chromatography, Cross couplings, Flash chromatography, Ligands

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Properties of Solvents Table

a. Gant, R., LC/GC 10 (7), 515 (1992) 1. At 20 °C 2. At 20 °C +/- 5 °C relative to water at 4 °C 3. At 10 mmHg pressure 4. At l=589.32 nm
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