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675970 Sigma-Aldrich

Cyclopentyl methyl ether

Green Alternative

contains 50 ppm BHT as inhibitor, anhydrous, ≥99.9%

Synonym: CPME

  • CAS Number 5614-37-9

  • Empirical Formula (Hill Notation) C6H12O

  • Molecular Weight 100.16

  •  MDL number MFCD08276401

  •  PubChem Substance ID 57652096

  •  NACRES NA.21



Related Categories Anhydrous Solvents, Greener Solvent Alternatives, Greener Substitutes, Solvent by Type, Solvent Bottles,
Quality Level   100
grade   anhydrous
assay   ≥99.9%
form   liquid
contains   50 ppm BHT as inhibitor
greener alternative product characteristics   Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.
impurities   ≤0.0050% H2O
  ≤0.0050% water
  ≤50 ppm H2O2
evapn. residue   <0.003%
bp   106 °C/760 mmHg
mp   -140 °C (lit.)
density   0.86 g/mL at 25 °C
greener alternative category   Aligned
InChI   1S/C6H12O/c1-7-6-4-2-3-5-6/h6H,2-5H2,1H3


General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. Cyclopentyl methyl ether (CPME) is a greener alternative to other ethereal solvents such as tetrahydrofuran (THF), 2-methyl tetrahydrofuran (2-MeTHF), dioxane (carcinogenic), tert-Butyl methyl ether (MTBE), and 1,2-dimethoxyethane (DME) and thus has been enhanced for "Safer Solvents and Auxiliaries". Click here for more information.


• Cyclopentyl methyl ether (CPME) is an alternative to ether solvents such as THF, diethyl ether, and MTBE with a higher resistance to peroxide formation.
• The more environmentally conservative CPME solvent replaces hazardous solvents in order to achieve sustainability and reduce environmental and operational costs.
• CPME offers considerable potential and advantage as a direct replacement for CH2Cl2 in binary eluents using MeOH as the modifier with MeOH–DMC and i-PrOH–EtOAc.

Green Alternative to THF, tert-Butyl methyl ether (MTBE), 1,4 Dioxane and other ether solvents

The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent.


1, 2 L in Sure/Seal™

100, 12×100 mL in Sure/Seal™

Features and Benefits

Greener alternative for THF, Diethyl ether, and MTBE

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
UN 3271 3 / PGII
WGK Germany 
Flash Point(F) 
30.2 °F - closed cup
Flash Point(C) 
-1 °C - closed cup


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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