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Piperine

analytical standard

Synonym: 1-Piperoylpiperidine

  • CAS Number 94-62-2

  • Empirical Formula (Hill Notation) C17H19NO3

  • Molecular Weight 285.34

  •  Beilstein/REAXYS Number 90741

  •  EC Number 202-348-0

  •  MDL number MFCD00005839

  •  PubChem Substance ID 329766089

  •  NACRES NA.24

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Properties

Related Categories Alkaloids / Nitrogen Containing Compounds, All Alphabetically Sorted, Alphabetical Index of Phytochemical Standards, Analytical Standards, Analytical/Chromatography,
Quality Level   100
grade   analytical standard
assay   ≥97.0% (HPLC)
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   131-135 °C (lit.)
Featured Industry   Cleaning Products
Cosmetics
Flavors and Fragrances
Food and Beverages
Personal Care
format   neat
storage temp.   2-8°C
SMILES string   O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3
InChI   1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
InChI key   MXXWOMGUGJBKIW-YPCIICBESA-N

Description

General description

Piperine is a naturally occurring bioactive alkaloid in pepper, which imparts pungency and bitter flavor to it. It has demonstrated health benefits and exhibits therapeutic properties, which include its role as an antimicrobial, antioxidant, antifungal, immunomodulatory and hepatoprotective agent. The inhibition of drug-metabolizing enzymes in hepatic and pulmonary tissues, and the enhancement of drug bioavailability by this compound are reported. It is also found to play an important role in reducing blood glucose, cholesterol and triglycerides.

Piperine is an amide isolated from the plant, Piper longum. It is a known inhibitor of hepatic and intestinal glucuronidation. Piperine is found to exhibit pharmacological properties like antitumor, antipyretic and anti-inflammatory activities.

Application

Piperine may be used as an analytical reference standard for the quantification of the analyte in:
• Human plasma using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
• Piper nigrum extract using reversed phase high pressure liquid chromatographic method with UV detection (RP-HPLC-UV).
• Food products using high-performance liquid chromatography with diode array detection (HPLC-DAD).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
RTECS 
TN2321500
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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