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75182 Supelco

Isoniazid

certified reference material, TraceCERT®

Synonym: 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide

  • CAS Number 54-85-3

  • Empirical Formula (Hill Notation) C6H7N3O

  • Molecular Weight 137.14

  •  Beilstein/REAXYS Number 119374

  •  EC Number 200-214-6

  •  MDL number MFCD00006426

  •  PubChem Substance ID 329766241

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Antibiotics / Drugs, Antibiotics Standards,
grade   certified reference material
InChI Key   QRXWMOHMRWLFEY-UHFFFAOYSA-N
grade   TraceCERT®
shelf life   limited shelf life, expiry date on the label
mp   171-173 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)

Description

General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034 (ISO Guide 34). This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Biochem/physiol Actions

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Legal Information

TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
RTECS 
NS1751850

Documents

Certificate of Analysis (COA)

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