EMAIL THIS PAGE TO A FRIEND
76307 Supelco

Pefabloc® SC

analytical standard

Synonym: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, AEBSF

  • CAS Number 30827-99-7

  • Empirical Formula (Hill Notation) C8H10FNO2S · HCl

  • Molecular Weight 239.69

  •  Beilstein/REAXYS Number 7604627

  •  MDL number MFCD00132962

  •  PubChem Substance ID 329767025

  •  NACRES NA.24

Purchase

Properties

Related Categories Additional Standards, Aliphatics, Amines, Analytical Standards, Analytical/Chromatography,
Quality Level   200
grade   analytical standard
InChI Key   WRDABNWSWOHGMS-UHFFFAOYSA-N
assay   ≥95.0% (HPLC)
form   powder or crystals
shelf life   5 yr
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   2-8°C

Description

General description

Pefabloc® SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Recommended concentrations for use are 0.1-1 mM.

Biochem/physiol Actions

Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25 mM.

Other Notes

Potent and irreversible inhibitor of serine proteases; in contrast to PMSF, it is water soluble and non-toxic; Unaffected by albumin

Legal Information

Pefabloc is a registered trademark of Pentapharm

Safety & Documentation

Safety Information

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?