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77608 Sigma-Aldrich

Phenol

BioUltra, for molecular biology, ≥99.5% (GC)

Synonym: Hydroxybenzene

  • CAS Number 108-95-2

  • Linear Formula C6H5OH

  • Molecular Weight 94.11

  •  Beilstein/REAXYS Number 969616

  •  EC Number 203-632-7

  •  MDL number MFCD00002143

  •  PubChem Substance ID 329767806

  •  NACRES NA.25

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Properties

Related Categories Acids and Bases, Alphabetical, BioUltra, Biochemicals and Reagents, Denaturation,
Quality Level   100
grade   for molecular biology
vapor density   3.24 (vs air)
vapor pressure   0.09 psi ( 55 °C)
  0.36 mmHg ( 20 °C)
product line   BioUltra
assay   ≥99.5% (GC)
form   solid
autoignition temp.   1319 °F
contains   ~0.15% hypophosphorous acid as stabilizer
expl. lim.   8.6 %
impurities   DNases, none detected
  RNases, none detected
  insoluble matter, passes filter test
  phosphatases, none detected
  proteases, none detected
  ≤0.5% water
ign. residue   ≤0.05%
pH   3.0-6.0 (25 °C, 0.5 M in H2O)
bp   182 °C (lit.)
mp   40-42 °C (lit.)
  40-42 °C
solubility   H2O: 0.5 M at 20 °C, clear, colorless
density   1.071 g/mL at 25 °C (lit.)
anion traces   chloride (Cl-): ≤5 mg/kg
  sulfate (SO42-): ≤50 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
SMILES string   Oc1ccccc1
absorption   cut-off at 294 nm in H2O at 0.5 M
suitability   suitable for molecular biology
storage temp.   2-8°C
InChI   1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H
InChI key   ISWSIDIOOBJBQZ-UHFFFAOYSA-N

Description

General description

Phenol/carbolic acid is mainly produced by hospital pharmacy as it is unavailable in premixed liquid form. It is not highly soluble in water. Phenol should be refrigerated and protected from light exposure to maintain its shelf life of approximately one year. Kidneys can excrete phenol as several conjugated derivatives.

Application

Phenol has been used in the incubation of pellet for RNA extraction.

Biochem/physiol Actions

Phenol has the ability to denature protein, hence can lead to denervation. At lower concentration, it can serve as a local anaesthetic and can also act as a neurolytic agent in higher concentration. It is also linked with tissue damage at higher concentrations.

Other Notes

For the preparation of DNA ; Large- and small-scale phenol extractions

Safety & Documentation

Safety Information

Signal word 
Danger
RIDADR 
UN 1671 6.1 / PGII
WGK Germany 
WGK 2
Flash Point(F) 
174.2 °F - closed cup
Flash Point(C) 
79.0 °C - closed cup
Protocols & Articles
Peer-Reviewed Papers
15

References

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