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78445 Supelco

Tetrahydrofuran

analytical standard

  • CAS Number 109-99-9

  • Empirical Formula (Hill Notation) C4H8O

  • Molecular Weight 72.11

  •  Beilstein/REAXYS Number 102391

  •  EC Number 203-726-8

  •  MDL number MFCD00005356

  •  PubChem Substance ID 329768151

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Properties

Related Categories Additional Standards, Alpha Sort, Analytical Standards, Analytical/Chromatography, Chemical Class,
grade   analytical standard
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
InChI Key   WYURNTSHIVDZCO-UHFFFAOYSA-N
assay   ≥99.9% (GC)
form   neat
autoignition temp.   610 °F
shelf life   limited shelf life, expiry date on the label
contains   ~0.025% 2,6-di-tert.-butyl-4-methylphenol as stabilizer
expl. lim.   11.8 %
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.407 (lit.)
bp   65-67 °C (lit.)
mp   −108 °C (lit.)
solubility   H2O: soluble
density   0.889 g/mL at 25 °C (lit.)
Featured Industry   Cosmetics, Personal Care, and Cleaning Products
Environmental
Food and Beverages
format   neat

Description

General description

Tetrahydrofuran is an important basic chemical compound, which belongs to the category of 5-membered heterocycles.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Tetrahydrofuran may find application as a solvent in the synthesis of (S)-2-(1-pyrrolidinylmethyl)pyrrolidine. It is also an excellent solvent for sodium diisopropylamide, which can find applications as an effective base for the isomerization of alkenes and metalation of 1,4-dienes.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
RIDADR 
UN 2056 3 / PGII
WGK Germany 
1
RTECS 
LU5950000
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C

Documents

Certificate of Analysis

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Protocols & Articles

Articles

GC Analysis of Class 3 Residual Solvents on Equity®-1 after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 3 Residual Solvents on Equity®-1 after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Class 3 Residual Solvents on Equity®-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 3 Residual Solvents on Equity®-5
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography

GC Analysis of Class 3 Residual Solvents on OVI-G43

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 3 Residual Solvents on OVI-G43
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography

GC Analysis of Class 3 Residual Solvents on SUPELCOWAX® 10

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 3 Residual Solvents on SUPELCOWAX® 10
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography

GC Analysis of Class 3 Residual Solvents on VOCOL® after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 3 Residual Solvents on VOCOL® after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Industrial Solvents on Equity®-1701

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1701
Keywords: Chromatography, Flame ionization detector, Gas chromatography

GC Analysis of Industrial Solvents on Equity®-1

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Industrial Solvents on SUPELCOWAX 10

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on SUPELCOWAX 10
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Solvents on a Packed Column (3% SP-1500 on Carbopack™ B)

From our library of Articles, Sigma-Aldrich presents GC Analysis of Solvents on a Packed Column (3% SP-1500 on Carbopack™ B)
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of a 12-Component Esters and Ethers Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column

From our library of Articles, Sigma-Aldrich presents GC Analysis of a 12-Component Esters and Ethers Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column
Keywords: Chromatography, Flame ionization detector, Gas chromatography

GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column

From our library of Articles, Sigma-Aldrich presents GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column
Keywords: Chromatography, Flame ionization detector, Gas chromatography

HPLC Analysis of Benoxaprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benoxaprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Coumachlor Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Coumachlor Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Environmental, Herbicides, High performance liquid chromatography, Pesticides, Pharmaceutical

HPLC Analysis of Coumafuryl Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Coumafuryl Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Environmental, Herbicides, High performance liquid chromatography, Pesticides

HPLC Analysis of Devrinol (Napropamide) Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Devrinol (Napropamide) Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Environmental, Herbicides, High performance liquid chromatography, Pesticides

HPLC Analysis of Fenoprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fenoprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Fenoterol Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fenoterol Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Flurbiprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Flurbiprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Ibuprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ibuprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Ketoprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ketoprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Luciferin Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Luciferin Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Naproxen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Naproxen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Sotalol Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sotalol Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Antihypertensives, Chromatography, High performance liquid chromatography, Pharmaceutical

Separation of UV-Filter on Silica gel 60

From our library of Articles, Sigma-Aldrich presents Separation of UV-Filter on Silica gel 60

The Utility of Headspace Grade Solvents for the Analysis of Organic Volatile Impurities

Organic volatile impurities or “OVIs” sometimes remain behind in pharmaceutical preparations as a result of synthetic and manufacturing procedures. For reasons of health and safety, testing is done t...
Katherine Stenerson, Shyam Verma
Reporter US Volume 28.1
Keywords: Chromatography, Gas chromatography, Organic synthesis, Pharmaceutical, Solvents

US EPA Method TO-17: GC Analysis of Volatiles on Equity®-1 after Collection/Desorption using Carbotrap 300 Tube

From our library of Articles, Sigma-Aldrich presents US EPA Method TO-17: GC Analysis of Volatiles on Equity®-1 after Collection/Desorption using Carbotrap 300 Tube
Keywords: Chromatography, Gas chromatography

Peer-Reviewed Papers
15

References

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Z683299 XPell indicating pellets for peroxides prevention, CE for organic solvents

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