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901989 Sigma-Aldrich

Tetrazine-NHS ester New

  • Empirical Formula (Hill Notation) C14H11N5O4

  • Molecular Weight 313.27

  •  MDL number MFCD29052194

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Description

Application

Tetrazine-NHS ester demonstrates exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile (up to 30,000 M-1 s-1). These have been the fastest kinetics reported for a bioorthogonal reaction. The chemical stability of tetrazines is substantially lower compared to methyltetrazines, thus requiring more careful selection of reagents and conditions for chemical transformation. However, tetrazine chemistry is still in an acceptable range for many applications.

Safety & Documentation

Safety Information

RIDADR 
transport forbidden

Documents

Certificate of Analysis

Protocols & Articles
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