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Retigabine

analytical standard

Synonym: D-23129, Ezogabine, N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester

  • CAS Number 150812-12-7

  • Empirical Formula (Hill Notation) C16H18FN3O2

  • Molecular Weight 303.33

  •  Beilstein/REAXYS Number 8072099

  •  MDL number MFCD04307735

  •  PubChem Substance ID 329769861

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites,
grade   analytical standard
InChI Key   PCOBBVZJEWWZFR-UHFFFAOYSA-N
assay   ≥98.0% (HPLC)
shelf life   limited shelf life, expiry date on the label
drug control   USDEA Schedule IV
impurities   ≤1.0% water (calc. from elemental analysis)
storage temp.   2-8°C

Description

General description

Retigabine is an antiepileptic drug, which activates neuronal KCNQ-type K+ channels by inducing a large hyperpolarizing shift of steady-state activation.

Application

Retigabine may be used as a reference standard in the determination of retigabine in biological matrices using high-performance liquid chromatography coupled with tandem mass spectrometry with positive ion atmospheric pressure chemical ionization (HPLC-APCI-MS/MS).

Biochem/physiol Actions

Retigabine (Ezogabine) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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