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Retigabine

analytical standard

Synonym: D-23129, Ezogabine, N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester

  • CAS Number 150812-12-7

  • Empirical Formula (Hill Notation) C16H18FN3O2

  • Molecular Weight 303.33

  •  Beilstein/REAXYS Number 8072099

  •  MDL number MFCD04307735

  •  PubChem Substance ID 329769861

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites,
Quality Level   100
grade   analytical standard
assay   ≥98.0% (HPLC)
shelf life   limited shelf life, expiry date on the label
drug control   USDEA Schedule IV
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
impurities   ≤1.0% water (calc. from elemental analysis)
Featured Industry   Forensics and Toxicology
Veterinary
storage temp.   2-8°C
SMILES string   FC1=CC=C(CNC2=CC(N)=C(NC(OCC)=O)C=C2)C=C1
InChI   1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
InChI key   PCOBBVZJEWWZFR-UHFFFAOYSA-N
Gene Information   human ... KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479)

Description

General description

Retigabine is an antiepileptic drug, which activates neuronal KCNQ-type K+ channels by inducing a large hyperpolarizing shift of steady-state activation.

Application

Retigabine may be used as a reference standard in the determination of retigabine in biological matrices using high-performance liquid chromatography coupled with tandem mass spectrometry with positive ion atmospheric pressure chemical ionization (HPLC-APCI-MS/MS).

Biochem/physiol Actions

Retigabine (Ezogabine) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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