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902292 Sigma-Aldrich

EvanPhos

≥95%

Synonym: Biaryl phosphine ligand for Pd catalysis, Dicyclohexyl(2,6-dimethoxy-3-(2-methoxynaphthalen-1-yl)phenyl)phosphane

  • CAS Number 2223634-83-9

  • Empirical Formula (Hill Notation) C31H39O3P

  • Molecular Weight 490.61

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Properties

Related Categories Catalysis and Inorganic Chemistry, Chemical Synthesis, Phosphine Compounds, Phosphine Ligands
assay   ≥95%
form   powder or crystals
mp   131-133 °C
functional group   phosphine
reaction suitability   reaction type: Buchwald-Hartwig Cross Coupling Reaction
  reaction type: Heck Reaction
  reaction type: Hiyama Coupling
  reaction type: Negishi Coupling
  reaction type: Sonogashira Coupling
  reaction type: Stille Coupling
  reaction type: Suzuki-Miyaura Coupling
  reagent type: ligand
reaction type: Cross Couplings

Description

Application

EvanPhos is a new biaryl phosphine ligand designed in the Lipshutz Lab as a Pd-complexed pre-catalyst for Suzuki-Miyaura cross couplings. Micellar catalysis was demonstrated with the surfactant TPGS-750-M, 2 wt. % in H2O (cat# 733857) and is an attractive technology for greener chemistry.

Other Notes

EvanPhos: a ligand for ppm level Pd-catalyzed Suzuki–Miyaura couplings in either organic solvent or water

Watch Professor Lipshutz talk about greener chemistry in this webinar: From milligrams to kilograms: synthetic chemistry following nature′s lead

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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