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905143 Sigma-Aldrich

(±)-cis-N-Boc-4-fluorocyclohexylamine

≥95%

  • CAS Number 1422966-97-9

  • Empirical Formula (Hill Notation) C11H20FNO2

  • Molecular Weight 217.28

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Description

Application

The incorporation of fluorine in agrochemical and pharmaceutical compounds is of high interest due to the ability to fine-tune the polarity, pKA-value, conformation and metabolic stability. Derived from a cis-selective hydrogenation developed by Glorius and coworkers, this fluorinated compound displays a diverse utility as a building block for chemical synthesis. Fluoro-cyclohexaneamine allows for the straightforward application in organic synthesis, after simple deprotection. It has been shown, that this compound can be used for the preparation of fluorinated analogs of Lomustine and Bromhexine.

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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