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909580 Sigma-Aldrich

TIPS-5-Ethynyl-dU-CEP

Synonym: TIPS-5-EdU CEP, TIPS-5-Ethynyl dU CEP, TIPS-5-Ethynyl dU phosphoramidite

  • Empirical Formula (Hill Notation) C50H67N4O8PSi

  • Molecular Weight 911.15

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Description

Application

This functional phosphoramidite is used to introduce click handles universally (5′ internal and 3′ end) into oligonucleotides under standard conditions for solid phase synthesis. Afterwards the oligonucleotide (RNA, PNA, DNA) can be efficiently conjugated using a copper catalyzed click reaction to azide functionalized moieties such as fluorescent dye azides and azido amino acids. In contrast to 5-Ethynyl dU CEP, TIPS-5-EdU CEP allows side product free synthesis of highly modified oligonucleotides (>10 modifications).

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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