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90964 Supelco

Hydrogen chloride solution

3 M in methanol, for GC derivatization, LiChropur

Synonym: Methanolic HCl

  • CAS Number 7647-01-0

  • Empirical Formula (Hill Notation) HCl

  • Molecular Weight 36.46

  •  MDL number MFCD00011324

  •  NACRES NA.05



Related Categories Acids, Acids & Bases, Alkylation Reagents, Analytical Reagents, Analytical/Chromatography,
Quality Level   100
grade   for GC derivatization
quality   LiChropur
concentration   3 M in methanol
density   0.871-0.881 g/mL at 20 °C
reaction suitability   reagent type: derivatization reagent
reaction type: Acylations
shipped in   dry ice
storage temp.   −20°C
SMILES string   Cl
InChI   1S/ClH/h1H


General description

Methanolic HCl (hydrogen chloride in methanol) is particularly useful for preparing methyl esters of volatile (short chain) fatty acids. Fatty acids are esterified by heating them with an anhydrous alcohol (e.g., methanol) in the presence of an acidic catalyst (e.g., HCl) in a sealed vessel at a high temperature for a short time. In the reaction, a fatty acid molecule and an alcohol molecule are joined, with the release of a water molecule. The derivatives can be quickly and easily recovered, quantitatively, from the reaction medium.


Suitable for derivatization of corticosteroids, estrogens, fatty acids, hop and beer bitter acids, lipids and formic and acetic acid (in cigarette smoke).

Features and Benefits

• Derivatization of fatty acids, particularly volatile (short chain) fatty acids
• Clean reaction (no side reaction) with volatile by-products
• Provides clean, fast, quantitative derivatization

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

UN 3286 8(6.1)(3) / PGII
Protocols & Articles

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