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91230 Sigma-Aldrich

Trichloroacetic acid

ACS reagent, for the determination of Fe in blood according to Heilmeyer, ≥99.5%

Synonym: TCA

  • CAS Number 76-03-9

  • Linear Formula Cl3CCOOH

  • Molecular Weight 163.39

  •  Beilstein/REAXYS Number 970119

  •  EC Number 200-927-2

  •  MDL number MFCD00004177

  •  PubChem Substance ID 57653429

  •  NACRES NA.21

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Properties

Related Categories Acids, Acids & Bases, Acids and Bases, Analytical Reagents, Analytical Reagents for General Use,
Quality Level   200
grade   ACS reagent
vapor density   <1 (vs air)
vapor pressure   1 mmHg ( 51 °C)
assay   ≥99.5% (T)
  ≥99.5%
quality   for the determination of Fe in blood according to Heilmeyer
ign. residue   ≤0.03% (as SO4)
refractive index   n20/D 1.62 (lit.)
bp   196 °C (lit.)
mp   54-58 °C (lit.)
solubility   water: soluble 81.7 g/L at 20 °C
density   1.62 g/mL at 25 °C (lit.)
anion traces   chloride (Cl-): ≤10 mg/kg
  nitrate (NO3-): ≤20 mg/kg
  phosphate (PO43-): ≤5 mg/kg
  sulfate (SO42-): ≤200 mg/kg
cation traces   Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg
SMILES string   OC(=O)C(Cl)(Cl)Cl
InChI   1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
InChI key   YNJBWRMUSHSURL-UHFFFAOYSA-N

Description

General description

Trichloroacetic acid (TCA) is a chlorinated acetic acid. It is one of the major metabolites of trichloroethylene (TCE).

Application

Trichloroacetic acid may be used in the following studies:
• Estimation of phosphorus in various biological samples (serum, urine and stool ash solutions).
• Elimination of acid-soluble and lipid phosphorous during the determination of deoxyribonucleic acid, ribonucleic acid and phosphoproteins in animal tissues.
• Preparation of 2-methyl-4-nitroanilinium trichloroacetate trichloroacetic acid (2M4NATCA) crystals.

10% Trichloroacetic acid may be employed for the preparation of radioactive proteins.

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Other Notes

Protein denaturant

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
UN 1839 8 / PGII
WGK Germany 
WGK 2
RTECS 
AJ7875000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

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