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Phloretin

analytical standard

Synonym: β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone, 2′,4′,6′-Trihydroxy-3-(4-hydroxyphenyl)propiophenone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone

  • CAS Number 60-82-2

  • Empirical Formula (Hill Notation) C15H14O5

  • Molecular Weight 274.27

  •  Beilstein/REAXYS Number 1887240

  •  EC Number 200-488-7

  •  MDL number MFCD00002288

  •  PubChem Substance ID 329770094

  •  NACRES NA.24

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Properties

Related Categories All Alphabetically Sorted, Alphabetical Index of Phytochemical Standards, Analytical Standards, Analytical/Chromatography, Apple,
Quality Level   100
grade   analytical standard
  analytical standard
assay   ≥98.5% (HPLC)
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
impurities   ≤8.0% water
mp   ~260 °C
Featured Industry   Cleaning Products
Cosmetics
Flavors and Fragrances
Food and Beverages
Personal Care
format   neat
SMILES string   Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
InChI   1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChI key   VGEREEWJJVICBM-UHFFFAOYSA-N

Description

General description

Phloretin is a dihydrochalcone flavonoid with antioxidant activity usually found in apples and apple-derived products. It is extensively used for peroxynitrite scavenging and the inhibition of lipid peroxidation.

Major polyphenol found in apple; aglycone of phloridzin.

Application

Phloretin may be used as an internal standard for the determination of sterols and diterpenoids in brown algae using high-performance liquid chromatography (HPLC).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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