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Isosilybin B

analytical standard

Synonym: (2R,3R)-3,5,7-Trihydroxy-2-[(2S,3S)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzo[1,4]dioxin-6-yl]-4-chromanone

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Properties

Related Categories Additional Standards, Alphabetical Index of Phytochemical Standards, Analytical Standards, Analytical/Chromatography, Chemical Class,
Quality Level   100
grade   analytical standard
assay   ≥80.0% (HPLC)
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Food and Beverages
format   neat
SMILES string   COc1cc(ccc1O)[C@@H]2Oc3ccc(cc3O[C@H]2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O
InChI   1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23-,24-,25+/m0/s1
InChI key   FDQAOULAVFHKBX-WAABAYLZSA-N

Description

General description

Isosilybin B is a flavonolignan and a bioactive component present in silymarin, isolated from Silybum marianum. It is commonly used in the treatment of cirrhosis, hepatitis and prevents the liver from being exposed to toxic substances.

Application

Isosilybin B may be used as an analytical reference standard for the quantification of the analyte in compound preparations of Silybum marianum and Silybum.miltiorrhiza using high-performance liquid chromatography with photo diode array detection and electrospray ionization-mass spectrometry.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Herbal Supplement Containing Milk Thistle on Ascentis® Express 2.7 μm C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Herbal Supplement Containing Milk Thistle on Ascentis® Express 2.7 μm C18
Keywords: Chromatography, High performance liquid chromatography, Separation, Vitamins

HPLC Analysis of Milk Thistle Standards on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Milk Thistle Standards on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Separation, Vitamins

HPLC Analysis of Silymarin on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Silymarin on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Separation, Vitamins

Peer-Reviewed Papers
15

References

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