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C1484 Sigma-Aldrich

7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin

≥95% (HPLC), solid

Synonym: 1H-Pyrrole-2,5-dione, 1-(4-(7-(diethylamino)-4-methyl-2-oxo-2H-1-benzopyran-3-yl)phenyl)-, CPM

  • CAS Number 76877-33-3

  • Empirical Formula (Hill Notation) C24H22N2O4

  • Molecular Weight 402.44

  •  MDL number MFCD00077334

  •  PubChem Substance ID 24892413

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, D, Fluorescent Labels, Fluorescent Probes, Labels, Particles and Stains,
InChI Key   YGIABALXNBVHBX-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   solid
color   yellow
solubility   DMSO: soluble
  methanol: soluble
storage temp.   −20°C

Description

General description

7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CPM), is a highly fluorescent, sulfhydryl (-SH) group containing coumarin derivative. It has excitation an emission wavelengths of 355 and 460 nm, respectively.

Application

7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin has been used:
• as a nontoxic substitute for conjugation with antibody(93)
• to aid fluorescent detection of Coenzyme A (CoA-SH) in human N-myristoyltransferases assay (94)
• in thermostability shift assay of recombinant protein(95)

Biochem/physiol Actions

Used to monitor release of thiols, quantitate thiol in microplate reactions, and to distinguish proliferating cancer cells by nucleolar protein staining.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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