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D7008 Sigma-Aldrich

Dihydroethidium

≥95%

Synonym: 2,7-Diamino-10-ethyl-9-phenyl-9,10-dihydrophenanthridine, 3,8-Diamino-5,6-dihydro-5-ethyl-6-phenylphenanthridine, Hydroethidine

  • CAS Number 104821-25-2

  • Empirical Formula (Hill Notation) C21H21N3

  • Molecular Weight 315.41

  •  Beilstein/REAXYS Number 5107482

  •  MDL number MFCD00077335

  •  PubChem Substance ID 24894069

  •  NACRES NA.47

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, D,
Quality Level   100
assay   ≥95%
form   powder
solubility   chloroform: 20 mg/mL
fluorescence   λex 370 nm; λem 420 nm (for cytoplasm of living cells)
  λex 535 nm; λem 610 nm (for chromatin of living cells)
storage temp.   −20°C
SMILES string   CCN1C(c2ccccc2)c3cc(N)ccc3-c4ccc(N)cc14
InChI   1S/C21H21N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,21H,2,22-23H2,1H3
InChI key   XYJODUBPWNZLML-UHFFFAOYSA-N

Description

Application

Redox indicator. Blue fluorescence until oxidized to ethidium.

Dihydroethidium has been used as a superoxide probe in bovine pulmonary artery endothelial cell (BPAEC). It has been used to check the in situ generation of ROS (reactive oxygen species).

Packaging

10 mg in poly bottle

Packaged under Argon.

Linkage

B-ring reduced analog of ethidium

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Mitochondrial Stress and ROS

Oxidative stress is implicated in the pathogenesis of lipotoxicity in both animal and human studies. Chronic oxidative stress is linked to insulin resistance in multiple tissues. Oxidative stress is ...
BioFiles 2011, 6.4, 22.
Keywords: Anti-inflammatory agents, Apoptosis, Cancer, Cell signaling, Cellular processes, Gene expression, Indicators, Metabolism, Oxidations, Respiratory

Peer-Reviewed Papers
15

References

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