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Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)

powder

Synonym: Di(N-succinimidyl) ethylene glycol disuccinate, EGS, Ethylene glycol bis(succinimidyl succinate), Ethylene glycol disuccinate di(N-succinimidyl) ester

  • CAS Number 70539-42-3

  • Empirical Formula (Hill Notation) C18H20N2O12

  • Molecular Weight 456.36

  •  Beilstein/REAXYS Number 9167119

  •  MDL number MFCD00049057

  •  PubChem Substance ID 24894501

  •  NACRES NA.47

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Properties

Related Categories Amine to Amine, Chemical Biology, Chemical Synthesis, Crosslinkers, Crosslinking,
Quality Level   200
form   powder
application(s)   hematology: suitable
  histology: suitable
solubility   acetic acid: water (1:1): ≤50 mg/mL
  DMF: soluble
Featured Industry   Diagnostic Assay Manufacturing
storage temp.   2-8°C
SMILES string   O=C(CCC(=O)ON1C(=O)CCC1=O)OCCOC(=O)CCC(=O)ON2C(=O)CCC2=O
InChI   1S/C18H20N2O12/c21-11-1-2-12(22)19(11)31-17(27)7-5-15(25)29-9-10-30-16(26)6-8-18(28)32-20-13(23)3-4-14(20)24/h1-10H2
InChI key   QLHLYJHNOCILIT-UHFFFAOYSA-N

Description

Packaging

1 g in poly bottle

250 mg in poly bottle

Application

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) has been used as a cross-linking agent.

Biochem/physiol Actions

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent. It is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer.

Features and Benefits

The ethylene glycol linkage is cleavable by hydroxylamine.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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