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I4386 Sigma-Aldrich

Iodoacetic acid

≥98.0% (T)

  • CAS Number 64-69-7

  • Linear Formula ICH2CO2H

  • Molecular Weight 185.95

  •  Beilstein/REAXYS Number 1739079

  •  EC Number 200-590-1

  •  MDL number MFCD00002685

  •  PubChem Substance ID 24896056

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Properties

Related Categories Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates,
InChI Key   JDNTWHVOXJZDSN-UHFFFAOYSA-N
assay   ≥98.0% (T)
form   powder or flakes
color   white to yellow
mp   77-79 °C (lit.)
solubility   H2O: soluble, clear to hazy
storage temp.   −20°C

Description

Application

Iodoacetic acid has been used as an alkylating agent for antibody AR37, serum proteins and strawberry proteome samples extracted from different stages of ripened fruit.

Reagent for the modification of cysteine residues in proteins.

Packaging

10, 25, 100 g in glass bottle

Biochem/physiol Actions

Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2923 6.1(8) / PGI
WGK Germany 
1
RTECS 
AI3500000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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