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ALD00604 Sigma-Aldrich

(+)-PSI Reagent

95%

Synonym: (+)-Ψ, (2R,3aR,6S,7aR)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, Phosphorus-Sulfur Incorporation Reagent

  • CAS Number 2245335-71-9

  • Empirical Formula (Hill Notation) C16H16F5OPS3

  • Molecular Weight 446.46

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling Reagents, Nucleoside Chemistry
assay   95%
form   powder or crystals
mp   102-107 °C

Description

Application

Air- and moisture-tolerant, this (+)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (−)-PSI Reagent, is also available (cat# ALD00602).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Other Notes

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

PSI on OpenFlask

Legal Information

PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Professor Product Portal - Baran Group

From our library of Articles, Sigma-Aldrich presents Professor Product Portal - Baran Group
Keywords: Building blocks, Fluorinations, Oxidations, Pharmaceutical

Peer-Reviewed Papers
15

References

Related Products

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Product #

Description

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