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B2883

bisBenzimide H 33258

≥98% (HPLC and TLC)

Synonym: 2′-(4-Hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5′-bi(1H-benzimidazole) trihydrochloride, 2-[2-(4-Hydroxyphenyl)-6-benzimidazoyl]-6-(1-methyl-4-piperazyl)benzimidazole trihydrochloride, BBIH, BXI-72, HOE 33258, Hoechst 33258, NSC334072

  • CAS Number 23491-45-4

  • Empirical Formula (Hill Notation) C25H24N6O · 3HCl

  • Molecular Weight 533.88

  •  Beilstein/REAXYS Number 4088183

  •  EC Number 245-690-6

  •  MDL number MFCD00012679

  •  PubChem Substance ID 24891414

  •  NACRES NA.47

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Properties

Related Categories Alphabetical, Apoptosis Detection, Apoptosis and Cell Cycle, B, Biochemicals and Reagents,
Quality Level   200
assay   ≥98% (HPLC and TLC)
form   powder
application(s)   hematology: suitable
  histology: suitable
mp   280 °C
solubility   H2O: 10 mg/mL
  water and ethanol: 10 mg/mL
  phosphate buffer: precipitates
suitability   passes application test for fluorescence
Featured Industry   Diagnostic Assay Manufacturing
storage temp.   −20°C
SMILES string   Cl[H].Cl[H].Cl[H].[H]O[H].CN1CCN(CC1)c2ccc3NC(=NCc3c2)c4ccc5NC(=NCc5c4)c6ccc(O)cc6
InChI   1S/C27H28N6O.3ClH.H2O/c1-32-10-12-33(13-11-32)22-5-9-25-21(15-22)17-29-27(31-25)19-4-8-24-20(14-19)16-28-26(30-24)18-2-6-23(34)7-3-18;;;;/h2-9,14-15,34H,10-13,16-17H2,1H3,(H,28,30)(H,29,31);3*1H;1H2
InChI key   OWRSPPSBNWJJAR-UHFFFAOYSA-N

Description

Application

bisBenzimide H 33258 is useful for staining DNA, chromosomes and nuclei. bisBenzimide H 33258 may be used for fluorescence microscopy or flow cytometry.
Excitation max. = 346 nm
Emission max. = 460 nm

bisBenzimide H 33258 has been used for nuclear staining in cells.

Packaging

1 g in glass bottle

100, 500 mg in glass bottle

25 mg in poly bottle

Biochem/physiol Actions

bisBenzimide H 33258 is a potent and selective Bcl-XL inhibitor. bisBenzimide H 33258 is a membrane-permeable, fluorescent DNA stain with low cytotoxicity that intercalate in A-T regions of DNA.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
SM1140500
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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