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B5887 Sigma-Aldrich

Sodium butyrate

≥98.5% (GC)

Synonym: Butyric acid sodium salt

  • CAS Number 156-54-7

  • Linear Formula CH3CH2CH2COONa

  • Molecular Weight 110.09

  •  Beilstein/REAXYS Number 3629439

  •  EC Number 205-857-6

  •  MDL number MFCD00002816

  •  PubChem Substance ID 24891873

  •  NACRES NA.25

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Properties

Related Categories Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents,
Quality Level   200
biological source   synthetic (organic)
assay   ≥98.5% (GC)
form   powder
mp   250-253 °C (lit.)
solubility   water: 100 mg/mL, clear to slightly hazy, colorless
storage temp.   room temp
SMILES string   [Na+].CCCC([O-])=O
InChI   1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChI key   MFBOGIVSZKQAPD-UHFFFAOYSA-M
Gene Information   mouse ... ENSMUSG00000061062(15181)

Description

Application

Sodium butyrate has been used:
• as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
• as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
• to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Packaging

1, 5 g in glass bottle

250 mg in glass bottle

Biochem/physiol Actions

Sodium butyrate is a short chain fatty acid inhibits histone deacetylase (HDAC) in millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Caution

Hygroscopic

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
ET6400000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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pHast Pack
Protocols & Articles

Articles

Histone Modification and Chromatin Remodeling

Gene expression is governed by complex mechanisms including transcription factor binding to DNA and coordinated changes in chromatin structure. The primary protein components of chromatin are the his...
Savita Bagga, PhD.
BioFiles v7 n3, 2012, 10–16
Keywords: Acetylations, Amplification, Cancer, Cell culture, Chromatin immunoprecipitation, Cloning, DNA purification, Diseases, Epigenetics, Gene expression, Immunoprecipitation, Indicators, Methylations, Microarray Analysis, Polymerase chain reaction, Polymerase chain reaction - quantitative, Polymorphisms, Purification, Sequencing, Transcription, Whole genome amplification

Peer-Reviewed Papers
15

References

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