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BP197

Hydroxycarbamide

British Pharmacopoeia (BP) Reference Standard

Synonym: Hydroxycarbamide, Hydroxyurea

  • CAS Number 127-07-1

  • Linear Formula NH2CONHOH

  • Molecular Weight 76.05

  •  Beilstein/REAXYS Number 1741548

  •  MDL number MFCD00007943

  •  NACRES NA.24

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Properties

grade   pharmaceutical primary standard
mfr. no.   BP
storage temp.   2-8°C
SMILES string   NC(=O)NO
InChI   1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key   VSNHCAURESNICA-UHFFFAOYSA-N
Gene Information   human ... RRM1(6240), RRM2(6241), RRM2B(50484)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.

Packaging

Unit quantity: 200 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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PHR2629 Hydroxyurea

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