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C0166000

Calcifediol

European Pharmacopoeia (EP) Reference Standard

Synonym: 25-Hydroxycholecalciferol, 25-Hydroxyvitamin D3 monohydrate

  • CAS Number 63283-36-3

  • Empirical Formula (Hill Notation) C27H44O2 · H2O

  • Molecular Weight 418.65

  •  Beilstein/REAXYS Number 4270041

  •  MDL number MFCD00867077

  •  PubChem Substance ID 329774765

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards C - D, Pharmacopeia & Metrological Institutes Standards More...
biological source   sheep wool (grease)
grade   pharmaceutical primary standard
Agency/Method   EP
form   neat
mfr. no.   EDQM
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   −20°C
SMILES string   [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O
InChI   1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
InChI key   JWUBBDSIWDLEOM-DTOXIADCSA-N
Gene Information   human ... VDR(7421)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.Calcifediol is a biologically active metabolite of vitamin D. It is more hydrophilic and better absorbed in the intestine when compared to ergocalciferol or cholecalciferol due to the high affinity for the vitamin-D-binding protein. The drug is known to treat diseases associated with decreased intestinal absorption and obesity.

Packaging

Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference subtance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of 25-Dihydroxyvitamin D2, 25-Hydroxyvitamin D3 and 3-epi-25-Hydroxyvitamin D3 on Ascentis® Express F5, 20 °C

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of 25-Dihydroxyvitamin D2, 25-Hydroxyvitamin D3 and 3-epi-25-Hydroxyvitamin D3 on Ascentis® Express F5, 20 °C
Keywords: Chromatography, Clinical, High performance liquid chromatography, Vitamins

HPLC Analysis of 25-Dihydroxyvitamin D2, 25-Hydroxyvitamin D3 and 3-epi-25-Hydroxyvitamin D3 on Ascentis® Express F5, 30 °C

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of 25-Dihydroxyvitamin D2, 25-Hydroxyvitamin D3 and 3-epi-25-Hydroxyvitamin D3 on Ascentis® Express F5, 30 °C
Keywords: Chromatography, Clinical, High performance liquid chromatography, Vitamins

HPLC Analysis of 25-Dihydroxyvitamin D2, 25-Hydroxyvitamin D3 and 3-epi-25-Hydroxyvitamin D3 on Ascentis® Express F5, 40 °C

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of 25-Dihydroxyvitamin D2, 25-Hydroxyvitamin D3 and 3-epi-25-Hydroxyvitamin D3 on Ascentis® Express F5, 40 °C
Keywords: Chromatography, Clinical, High performance liquid chromatography, Vitamins

HPLC Analysis of 25-Hydroxyvitamin D3 and 25-Hydroxyvitamin D2 on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of 25-Hydroxyvitamin D3 and 25-Hydroxyvitamin D2 on Ascentis® Express F5
Keywords: Chromatography, Clinical, High performance liquid chromatography, Vitamins

HPLC Analysis of 25-Hydroxyvitamin D3 and epi-25-Hydroxyvitamin D3 on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of 25-Hydroxyvitamin D3 and epi-25-Hydroxyvitamin D3 on Ascentis® Express F5
Keywords: Chromatography, Clinical, High performance liquid chromatography, Vitamins

LC/MS Analysis of 25-Hydroxyvitamin D2 and 25-Hydroxyvitamin D3 on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of 25-Hydroxyvitamin D2 and 25-Hydroxyvitamin D3 on Ascentis® Express F5
Keywords: Chromatography, Clinical, High performance liquid chromatography, Indicators, Liquid chromatography mass spectrometry, Mass spectrometry, Solvents, Vitamins

LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5 (Monitored Ions)

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5 (Monitored Ions)
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solvents, Vitamins

LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Solvents, Vitamins

LC/MS/MS of 25-Dihydroxyvitamin D2, 25-Hydroxyvitamin D3, and 3-epi-25-Hydroxyvitamin D3 in Serum or Plasma on Ascentis® Express F5 after SPE with HybridSPE®-Phospholipid, Minimization of Matrix Effects

From our library of Articles, Sigma-Aldrich presents LC/MS/MS of 25-Dihydroxyvitamin D2, 25-Hydroxyvitamin D3, and 3-epi-25-Hydroxyvitamin D3 in Serum or Plasma on Ascentis® Express F5 after SPE with HybridSPE®-Phospholipid, Minimization of Matrix Effects
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Sample preparations, Solid phase extractions, Vitamins

Peer-Reviewed Papers
15

References

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PHR2359 Calcifediol, Pharmaceutical Secondary Standard; Certified Reference Material
06693 Timestrip Plus -20 °C

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