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C0250000 Sigma-Aldrich

Calcium folinate

European Pharmacopoeia (EP) Reference Standard

Synonym: 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Folinic acid calcium salt hydrate, Leucovorin calcium salt

  • CAS Number 1492-18-8 (anhydrous)

  • Empirical Formula (Hill Notation) C20H21CaN7O7 · xH2O

  • Molecular Weight 511.50 (anhydrous basis)

  •  Beilstein/REAXYS Number 5723924

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards C - D, Pharmacopeia & Metrological Institutes Standards More...
biological source   synthetic
form   neat
Agency/Method   EP
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   2-8°C

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. Calcium folinate (CF) is a folic acid derivative. It is a naturally occurring compound that has a vital role in various metabolic pathways. Calcium folinate (CF) drug is also used in the treatment of anemia, during pregnancy.

Application

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.

Packaging

Unit quantity: 110 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference subtance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Folinic Acid Enantiomers on Astec® CHIROBIOTIC® T (RP mode)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Folinic Acid Enantiomers on Astec® CHIROBIOTIC® T (RP mode)
Keywords: Antitumor agents, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Folinic Acid Enantiomers on Astec® CHIROBIOTIC® T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Folinic Acid Enantiomers on Astec® CHIROBIOTIC® T
Keywords: Antitumor agents, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

Peer-Reviewed Papers
15

References

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08168 Timestrip Plus 8 °C
PHR1541 Leucovorin Calcium, Pharmaceutical Secondary Standard; Certified Reference Material

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