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C1357 Sigma-Aldrich

Cholecalciferol

meets USP testing specifications

Synonym: (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol

  • CAS Number 67-97-0

  • Empirical Formula (Hill Notation) C27H44O

  • Molecular Weight 384.64

  •  Beilstein/REAXYS Number 2339331

  •  EC Number 200-673-2

  •  MDL number MFCD00078131

  •  eCl@ss 34058003

  •  PubChem Substance ID 24892404

  •  NACRES NA.21

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Properties

Related Categories Analytical/Chromatography, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents,
Quality Level   200
assay   97.0-103.0%
form   crystalline
color   white
mp   83-86 °C (lit.)
suitability   meets USP testing specifications
Featured Industry   Pharmaceutical (small molecule)
storage temp.   2-8°C
SMILES string   CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
InChI   1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChI key   QYSXJUFSXHHAJI-YRZJJWOYSA-N
Gene Information   human ... VDR(7421)

Description

General description

Cholecalciferol (vitamin D3), a fat-soluble steroid is produced in the skin.

Application

Cholecalciferol has been used:
• to induce arterial medial calcification (AMC) in mice
• to study its impact in vascular remodeling associated with vascular calcification (VC) in murine model of obesity and insulin resistance (ob/ob mice)
• to study its effect on anchorage dependent growth of RWPE2-W99 cells in monolayer culture

Packaging

1 g in ampule

25 g in glass bottle

250 mg in ampule

Biochem/physiol Actions

Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
WGK 2
RTECS 
VS2900000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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