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  • C3434 - Sodium citrate tribasic dihydrate

C3434 Sigma-Aldrich

Sodium citrate tribasic dihydrate

BioXtra, ≥99.0% (titration)

Synonym: Citric acid trisodium salt dihydrate, Trisodium citrate dihydrate

  • CAS Number 6132-04-3

  • Linear Formula HOC(COONa)(CH2COONa)2 · 2H2O

  • Molecular Weight 294.10

  •  Beilstein/REAXYS Number 6104939

  •  EC Number 200-675-3

  •  MDL number MFCD00150031

  •  PubChem Substance ID 24892616



Related Categories BioXtra Buffers, Biochemicals and Reagents, Biological Buffers, Buffers A to Z, Cancer Metabolism,
product line   BioXtra
assay   ≥99.0% (titration)
impurities   Insoluble matter, passes filter test
pH   7.5-9.0 (20 °C, 0.1 M in H2O)
mp   >300 °C (lit.)
solubility   H2O: 0.1 M at 20 °C, clear, colorless
anion traces   chloride (Cl-): ≤0.001%
  sulfate (SO42-): ≤0.005%
cation traces   Al: ≤0.0005%
  As: ≤0.00001%
  Ba: ≤0.0005%
  Bi: ≤0.0005%
  Ca: ≤0.005%
  Cd: ≤0.0005%
  Co: ≤0.0005%
  Cr: ≤0.0005%
  Cu: ≤0.0005%
  Fe: ≤0.0005%
  K: ≤0.01%
  Li: ≤0.0005%
  Mg: ≤0.0005%
  Mn: ≤0.0005%
  Mo: ≤0.0005%
  NH4+: ≤0.001%
  Ni: ≤0.0005%
  Pb: ≤0.0005%
  Zn: ≤0.0005%
absorption   ≤0.010 at 260 in H2O at 0.1 M
  ≤0.010 at 280
SMILES string   O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
InChI   1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3


Biochem/physiol Actions

Sodium citrate can act as a buffering agent, resisting changes in pH. Used in blood collection tubes, the citrate chelates calcium ions in blood and thereby disrupts blood clotting. Citrate is a intermediate in the TCA cycle and fatty acid synthesis. Citrate is an allosteric modulator of acetyl-CoA carboxylase, the enzyme that regulates the conversion of acetyl-CoA to malonyl-CoA.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles


Fatty Acid Synthesis and Metabolism in Cancer Cells

Proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sour...
BioFiles v7 n4
Keywords: Apoptosis, Cancer, Carboxylations, Catalysis, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Oxidations, Phosphorylations

Glutamine Metabolism is Dysregulated in Many Cancer Cells

Proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metab...
BioFiles v7 n4
Keywords: Aerobic, Cancer, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Metabolites, Phosphorylations, Transcription

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