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C5901 Supelco

Codeine monohydrate

analytical standard

  • CAS Number 6059-47-8

  • Empirical Formula (Hill Notation) C18H21NO3 · H2O

  • Molecular Weight 317.38

  •  MDL number MFCD01940504

  •  PubChem Substance ID 329775106

  •  NACRES NA.24

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Properties

Related Categories 1694 Pharmaceuticals & Personal Care Products, Additional Standards, Alkaloids, Analytical Standards, Analytical/Chromatography,
Quality Level   200
grade   analytical standard
Agency/Method   EPA 1694
form   neat
drug control   USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Environmental
Forensics and Toxicology
Pharmaceutical (small molecule)
Veterinary
format   neat
storage temp.   2-8°C
SMILES string   CN1[C@H](C2)[C@@]3([H])[C@@]4(CC1)C5=C2C=CC(OC)=C5O[C@@]4([H])[C@@H](O)C=C3.O
InChI   1S/C18H21NO3.H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;/h3-6,11-13,17,20H,7-9H2,1-2H3;1H2/t11-,12+,13-,17-,18-;/m0./s1
InChI key   WRRSFOZOETZUPG-FFHNEAJVSA-N
Gene Information   human ... CYP2D6(1565), OPRD1(4985), OPRK1(4986), OPRM1(4988)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)

Description

Application

Codeine monohydrate has been used as a standard in the quantitative analysis of codeine by using different types of protein assays like biuret, bicinchoninic acid (BCA), coomassie brilliant blue (CBB) , pyrogallol red–molybdate (PRM) assay, Lowry assay and benzethonium chloride (BEC) assay, while relating the effective response of the drug with the type of assay.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Weak narcotic analgesic, perhaps due to conversion to morphine, with minimal hypnotic properties; potent antitussive

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Polar Compounds on Ascentis® Express OH5 (HILIC Mode)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Polar Compounds on Ascentis® Express OH5 (HILIC Mode)
Keywords: Analgesics, Chromatography, Herbicides, High performance liquid chromatography, Ion Exchange, Pesticides, Pharmaceutical

TLC Analysis of Alkaloids by Ion-Pair Chromatography on HPTLC Silica Gel 60 RP-8 F254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Alkaloids by Ion-Pair Chromatography on HPTLC Silica Gel 60 RP-8 F254s
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

TLC Analysis of Morphine Derivatives by Ion-Pair Chromatography on HPTLC Silica Gel 60 RP-18 WF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Morphine Derivatives by Ion-Pair Chromatography on HPTLC Silica Gel 60 RP-18 WF254s
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

TLC analysis of Catecholamines by ion-pair chromatography on TLC pre-coated plate RP-8 F 254s

From our library of Articles, Sigma-Aldrich presents TLC analysis of Catecholamines by ion-pair chromatography on TLC pre-coated plate RP-8 F 254s
Keywords: Thin layer chromatography

Peer-Reviewed Papers
15

References

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