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C8731 Sigma-Aldrich

Calcium pantothenate

meets USP testing specifications, monograph mol wt. 476.53 (C18H32CaN2O10)

Synonym: (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, D-Pantothenic acid hemicalcium salt, Calcium D-pantothenate, Vitamin B5

  • CAS Number 137-08-6

  • Linear Formula HOCH2C(CH3)2CH(OH)CONHCH2CH2CO2 ·1/2Ca

  • Molecular Weight 238.27

  •  Beilstein/REAXYS Number 3769272

  •  EC Number 205-278-9

  •  MDL number MFCD00002766

  •  eCl@ss 34058012

  •  PubChem Substance ID 24893098

  •  NACRES NA.21

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Properties

Related Categories Analytical/Chromatography, Biochemicals and Reagents, Cell Culture, Core Bioreagents, Pharmacopoeia,
Quality Level   200
biological source   synthetic (organic)
Agency/Method   meets USP testing specifications
form   crystalline
  powder
mol wt   monograph mol wt. 476.53 (C18H32CaN2O10)
application(s)   cell culture | mammalian: suitable
  cell culture | plant: suitable
color   white
Featured Industry   Pharmaceutical (small molecule)
storage temp.   2-8°C
SMILES string   CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO
InChI   1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1
InChI key   FAPWYRCQGJNNSJ-UBKPKTQASA-L

Description

General description

Vitamin B5 or pantothenic acid is a viscous oil that is soluble in ethanol and water. It is produced by plants and microorganisms. d-(+)pantothenic acid is the naturally occurring form of pantothenic acid and is biologically active.

Application

Calcium pantothenate has been used:
• as a component of vitamin solution for synthetic media
• as a component of vitamin mix for the ICS medium mix
• as a component of a chemically defined diet for metal depletion studies in Drosophila
• as a supplement to study coenzyme A metabolism in mouse models of non-alcoholic steatohepatitis

Precursor in the biosynthesis of coenzyme A.

Packaging

1 kg in poly bottle

25, 100 g in poly bottle

Biochem/physiol Actions

The calcium salts of panthenol are commonly used for pharmaceutical preparations. Pantothenate is a component of coenzyme A and is useful in its synthesis. Pantothenic acid is also involved in the synthesis of heme, cholesterol and fatty acids. Since vitamin B5 is found in all foods, its deficiency is not commonly observed.

Physical properties

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
RU4375000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
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References

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