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D0940000 Sigma-Aldrich

Diazepam

European Pharmacopoeia (EP) Reference Standard

Synonym: 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one, Ro 5-2807

  • CAS Number 439-14-5

  • Empirical Formula (Hill Notation) C16H13ClN2O

  • Molecular Weight 284.74

  •  MDL number MFCD00057323

  •  PubChem Substance ID 329798654

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards C - D, Pharmacopeia & Metrological Institutes Standards More...
InChI Key   AAOVKJBEBIDNHE-UHFFFAOYSA-N
form   neat
drug control   USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   2-8°C

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Diazepam is a benzodiazepine anxiolytic agent. It serves as a prototype ligand for the GABAA receptor benzodiazepine modulatory site.

Packaging

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference subtance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
UN 2811 6.1 / PGIII

Documents

Certificate of Analysis

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Protocols & Articles

Articles

GC Analysis of Basic Drugs on Equity®-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on Equity®-5
Keywords: Chromatography, Gas chromatography, Purification

GC Analysis of Basic Drugs on SLB®-5ms (20 m x 0.18 mm I.D., 0.36 μm) after SPME using 65 μm PDMS/DVB Fiber, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on SLB®-5ms (20 m x 0.18 mm I.D., 0.36 μm) after SPME using 65 μm PDMS/DVB Fiber, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Mass selective detector, Purification, Solid phase microextractions

GC Analysis of Basic Drugs on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Purification

HPLC Analysis of Antianxiety Drugs on Ascentis® Express C18 vs. Standard C18, Demonstrating High Throughput on Ascentis Express

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antianxiety Drugs on Ascentis® Express C18 vs. Standard C18, Demonstrating High Throughput on Ascentis Express
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Antianxiety Drugs on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antianxiety Drugs on Ascentis® Phenyl
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Anticonvulsant Drugs on Discovery® RP-AmideC16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Anticonvulsant Drugs on Discovery® RP-AmideC16
Keywords: Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Anticonvulsants on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Anticonvulsants on Discovery® C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Anticonvulsants on Discovery® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Anticonvulsants on Discovery® C8
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Anxiolytic Drugs on SUPELCOSIL™ LC-8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Anxiolytic Drugs on SUPELCOSIL™ LC-8
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Benzodiazepines on Ascentis® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzodiazepines on Ascentis® C8
Keywords: Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Pharmaceutical

HPLC Analysis of Benzodiazepines on Ascentis® Express C18, Acetonitrile Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzodiazepines on Ascentis® Express C18, Acetonitrile Mobile Phase
Keywords: Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Benzodiazepines on Ascentis® Express Phenyl-Hexyl with Acetonitrile Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzodiazepines on Ascentis® Express Phenyl-Hexyl with Acetonitrile Mobile Phase
Keywords: Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Benzodiazepines on Ascentis® Express Phenyl-Hexyl, Methanol Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzodiazepines on Ascentis® Express Phenyl-Hexyl, Methanol Mobile Phase
Keywords: Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

LC/MS Analysis of Benzodiazepines on Ascentis® Phenyl (Analyte Mix 1)

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Benzodiazepines on Ascentis® Phenyl (Analyte Mix 1)
Keywords: Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Pharmaceutical

LC/MS/MS Analysis of Drugs in Plasma on Ascentis® Express C18 after Extraction using SPME LC Tips

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Drugs in Plasma on Ascentis® Express C18 after Extraction using SPME LC Tips
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Separation, Solid phase microextractions

RP-HPLC Analysis of Benzodiazepines on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents RP-HPLC Analysis of Benzodiazepines on Ascentis® Express Biphenyl
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

UHPLC Analysis of Deuterated Isomers on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Deuterated Isomers on Titan™ C18
Keywords: Anticonvulsants, Chromatography

UHPLC Analysis of Diazepam and Metabolites on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Diazepam and Metabolites on Ascentis® Express C18
Keywords: Chromatography, Clinical

UHPLC Analysis of Diazepam and Metabolites on Titan™ C18, Competitive Comparison

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Diazepam and Metabolites on Titan™ C18, Competitive Comparison
Keywords: Anti-depressants, Anticonvulsants, Chromatography, Clinical, Mass spectrometry, Metabolites, Pharmaceutical

UHPLC/MS Analysis of Diazepam and Metabolites on Titan™ C18, Comparison of Flow Rate and Column Length

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Diazepam and Metabolites on Titan™ C18, Comparison of Flow Rate and Column Length
Keywords: Anti-depressants, Anticonvulsants, Chromatography, Solvents

UHPLC/MS Analysis of Drugs in Whole Blood on Titan™ C18 after Biocompatible Solid Phase Microextraction (BioSPME) using SPME LC Tips with C18 °Chemistry

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Drugs in Whole Blood on Titan™ C18 after Biocompatible Solid Phase Microextraction (BioSPME) using SPME LC Tips with C18 °Chemistry
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Mass spectrometry, Sample preparations, Separation, Solid phase microextractions, Solvents

UHPLC/MS Analysis of Heroin and Related Compounds on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Heroin and Related Compounds on Titan™ C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

UHPLC/MS Analysis of Various Drug Substances on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Various Drug Substances on Titan™ C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

UHPLC/MS/MS Analysis of Benzodiazepines and Glucuronide Metabolites in Urine on Titan™ C18 after SPE using Supel™-Select HLB, β-Glucuronidase Enzyme Digestion

From our library of Articles, Sigma-Aldrich presents UHPLC/MS/MS Analysis of Benzodiazepines and Glucuronide Metabolites in Urine on Titan™ C18 after SPE using Supel™-Select HLB, β-Glucuronidase Enzyme Digestion
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Mass spectrometry, Metabolites, Pharmaceutical, Sample preparations, Solid phase extractions

Peer-Reviewed Papers
15

References

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