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D125806 Sigma-Aldrich

N,N-Diisopropylethylamine

ReagentPlus®, ≥99%

Synonym: ‘Hünig’s base’, N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine

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Properties

grade   ReagentPlus®
vapor pressure   31 mmHg ( 37.7 °C)
InChI Key   JGFZNNIVVJXRND-UHFFFAOYSA-N
assay   ≥99%
refractive index   n20/D 1.414 (lit.)
bp   127 °C(lit.)
mp   <−50 °C (lit.)
density   0.742 g/mL at 25 °C (lit.)

Description

General description

N,N-Diisopropylethylamine, also known as Hünig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed for substitution reactions. It acts as an activator for chiral iridium N, P ligand complexes, which can be utilized in the hydrogenation of α, β-unsaturated nitriles. The influence of varying concentration of N,N-diisopropylethylamine on the synthesis of olvanil in the presence of lipase catalyst has been investigated.

Application

N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.

Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.

Packaging

1, 2.5 L in glass bottle

10, 50 L in composite drum

100, 4×100, 500 mL in glass bottle

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3384 3(6.1) / PGI
WGK Germany 
2
Flash Point(F) 
53.6 °F
Flash Point(C) 
12 °C

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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