D3525 Sigma-Aldrich


analytical standard

Synonym: 3′,5,7-Trihydroxy-4′-methoxyflavone 7-rutinoside



Biochem/physiol Actions

Citrus flavonoid. Modification of hesperidin. Studied for its chemopreventive properties, including anti-proliferative and anti-inflammatory.


5, 25 g in poly bottle


Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D3525.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit

Price and Availability

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option:
How should Product D3525, Diosmin, be dissolved?
Diosmin is soluble in DMSO at 10 mM, per following paper: Zhang, S., et al., “Flavonoids as Aryl Hydrocarbon Receptor Agonists/Antagonists: Effects of Structure and Cell Context.” Environ. Health. Perspect., 111, 1877-1882 (2003).
Is Product D3525, Diosmin, synthetic or from a natural source?
Diosmin is typically isolated from a plant source (orange or lemon). This information can be found on Certificate of Origin (CofO lot-specific). The link to CofO is located on the Product Detail Page. Click on the link below to access the Product Detail Page for D3525:
Does Product D3525, diosmin absorb in the UV spectrum?  If so, what is the λmax?
Yes. Diosmin has the following UV absorbance properties: λmax: 255 nm, 268 nm, 345 nm (ethanol) Extinction coefficient: EmM = 19.05, 17.78, and 19.95. Referenced from:  Merck Index, 10th ed., Entry# 3300.
Product D3525, Diosmin, is a rutinoside derivative. Does Sigma-Aldrich list any other rutinosides?
Yes, we have two others:  H5254, Hesperidin and 36428, Keracynin chloride.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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