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D4784 Sigma-Aldrich

4,5-Methylenedioxy-1,2-phenylenediamine dihydrochloride

Fluorogenic reagent

Synonym: 1,2-Diamino-4,5-methylenedioxybenzene dihydrochloride, 1,3-Benzodioxole-5,6-diamine dihydrochloride, 5,6-Diamino-1,3-benzodioxole dihydrochloride, MDB

  • CAS Number 81864-15-5

  • Empirical Formula (Hill Notation) C7H8N2O2 · 2HCl

  • Molecular Weight 225.07

  •  Beilstein/REAXYS Number 5641607

  •  MDL number MFCD00037497

  •  PubChem Substance ID 24893897

  •  NACRES NA.47

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Derivatization agents, Hematology and Histology, Luminescent Compounds/Detection,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
application(s)   hematology: suitable
  histology: suitable
mp   247 °C
solubility   H2O: 50 mg/mL
Featured Industry   Diagnostic Assay Manufacturing
storage temp.   −20°C
SMILES string   Cl[H].Cl[H].Nc1cc2OCOc2cc1N
InChI   1S/C7H8N2O2.2ClH/c8-4-1-6-7(2-5(4)9)11-3-10-6;;/h1-2H,3,8-9H2;2*1H
InChI key   YXEJRYIEFFUUID-UHFFFAOYSA-N

Description

General description

4,5-Methylenedioxy-1,2-phenylenediamine dihydrochloride is a fluorescence tag for α keto acids. It is also required for the derivatization of sialic acids in presence of dilute sulfuric acid. The method allows determination of sialic acids.

Application

4,5-Methylenedioxy-1,2-phenylenediamine dihydrochloride has been used for the derivatization of sialic acids to analyse them by capillary liquid-chromatography-electrospray ionization/tandem mass spectrometry (CapLC-ESI-MS/MS).

Fluorogenic reagent for α-ketoacids.

Packaging

10, 50 mg in glass insert

100 mg in poly bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Improving the Chromatographic Separation of DMB-Labeled Sialic Acids for the Comparison of Biosimilars to Reference Materials

Sialic acids are N- or O-substituted derivatives of neuraminic acid. They are important because they affect bioavailability, function, stability, and metabolism of glycoproteins. Two forms of sialic ...
Xiaoning Lu, Isil Yasa, Ben Cutak, Kevin Ray, David S. Bell
Reporter US Volume 33.2
Keywords: High performance liquid chromatography, Metabolism, Separation, Solvents

Peer-Reviewed Papers
15

References

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