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D54702 Sigma-Aldrich

Dichloroacetic acid

ReagentPlus®, ≥99%

  • CAS Number 79-43-6

  • Linear Formula Cl2CHCOOH

  • Molecular Weight 128.94

  •  Beilstein/REAXYS Number 1098596

  •  EC Number 201-207-0

  •  MDL number MFCD00004223

  •  PubChem Substance ID 24893838

  •  NACRES NA.21

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Properties

Related Categories Acids, Acids & Bases, Aerobic Glycolysis (the Warburg Effect), Cancer Metabolism, Cancer Research,
Quality Level   200
grade   ReagentPlus®
vapor density   4.5 (vs air)
vapor pressure   0.19 mmHg ( 20 °C)
assay   ≥99%
form   liquid
refractive index   n20/D 1.466 (lit.)
bp   194 °C (lit.)
mp   9-11 °C (lit.)
density   1.563 g/mL at 25 °C (lit.)
storage temp.   2-8°C
SMILES string   OC(=O)C(Cl)Cl
InChI   1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)
InChI key   JXTHNDFMNIQAHM-UHFFFAOYSA-N
Gene Information   human ... ALDH1A1(216), PDK1(5163)
rat ... Pdk1(116551)

Description

General description

Dichloroacetic acid (DCA) is a chlorinated acetic acid that has been reported to be a mouse liver carcinogen. The varying degrees of swelling of polyester in different concentrations of DCA solution has been analyzed by phase-contrast microscopy. The efficiency of titanium dioxide (TiO2) nanoparticles to catalyze the photodegradation of DCA has been investigated.

Application

Dichloroacetic acid (DCA) can be used as:
•  A reactant in the synthesis of chloroketones by reacting with esters in the presence of LiHMDS via Claisen-type homologation reaction.
•  A structure-directing agent, solvent, or plastdopant for the preparation of different morphologies of polyaniline (PANI). Self-assembling nanostructured PANI may be formed due to the presence of strong hydrogen bonding between DCA and aniline/polyaniline.

Packaging

100, 4×100, 500 mL in glass bottle

2.5 L in glass bottle

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Danger
Supplemental Hazard Statements 
EUH071
RIDADR 
UN 1764 8 / PGII
WGK Germany 
WGK 2
RTECS 
AG6125000
Flash Point(F) 
235.4 °F - closed cup
Flash Point(C) 
113 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
BioFiles v7 n4
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, Phosphorylations, Transcription

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References

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