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D6003 Supelco

Digoxin

analytical standard

Synonym: 12β-Hydroxydigitoxin

  • CAS Number 20830-75-5

  • Empirical Formula (Hill Notation) C41H64O14

  • Molecular Weight 780.94

  •  Beilstein/REAXYS Number 77011

  •  EC Number 244-068-1

  •  MDL number MFCD00003674

  •  PubChem Substance ID 329798818

  •  NACRES NA.24

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Application Index, Biochemicals and Reagents,
Quality Level   100
biological source   plant (Digitalis lanata)
grade   analytical standard
assay   ≥95.0% (HPLC)
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
solubility   methanol: methylene chloride (1:1): 0.5%, clear, colorless
Featured Industry   Food and Beverages
Forensics and Toxicology
Veterinary
format   neat
functional group   ketone
shipped in   ambient
storage temp.   room temp
SMILES string   C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]2[C@@H](O)C[C@@H](O[C@@H]2C)O[C@H]3[C@@H](O)C[C@@H](O[C@@H]3C)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4
InChI   1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1
InChI key   LTMHDMANZUZIPE-PUGKRICDSA-N
Gene Information   human ... ATP1A1(476), ATP1A2(477), ATP1A3(478), ATP1A4(480), ATP1B1(481), ATP1B2(482), ATP1B3(483), FXYD2(486)

Description

Application

Digoxin may be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

1, 5 g in glass bottle

100 mg in glass bottle

Biochem/physiol Actions

A cardiac glycoside, substrate for Pgp, upregulates Pgp expression and down regulates SXR (Steroid Xenobiotic Receptor).

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3462 6.1 / PGII
WGK Germany 
WGK 3
RTECS 
IH6125000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Steroidal Glycosides on Ascentis® Phenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroidal Glycosides on Ascentis® Phenyl
Keywords: Chromatography, High performance liquid chromatography, Vitamins

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18
Keywords: Antihypertensives, Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Precipitation, Solid phase extractions

LC/MS/MS of Digoxin and Digitoxin in Serum or Plasma on Titan™ C18 after SPE with HybridSPE®-Phospholipid, Minimization of Matrix Effects

From our library of Articles, Sigma-Aldrich presents LC/MS/MS of Digoxin and Digitoxin in Serum or Plasma on Titan™ C18 after SPE with HybridSPE®-Phospholipid, Minimization of Matrix Effects
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Solid phase extractions, Solvents

LC/MS/MS of Digoxin and Digitoxin in Serum or Plasma on Titan™ C18 after SPE with HybridSPE®-Phospholipid, Minimization of Matrix Effects

From our library of Articles, Sigma-Aldrich presents LC/MS/MS of Digoxin and Digitoxin in Serum or Plasma on Titan™ C18 after SPE with HybridSPE®-Phospholipid, Minimization of Matrix Effects
Keywords: Chromatography, High performance liquid chromatography, Immunoassay, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Separation, Solid phase extractions, Solvents

TLC Analysis of Benzoic Acid and Sorbic Acid on HPTLC CN F254s (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Benzoic Acid and Sorbic Acid on HPTLC CN F254s (analyte set 2)
Keywords: Chromatography, Thin layer chromatography

Peer-Reviewed Papers
15

References

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