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D6518 Sigma-Aldrich

Diethylenetriaminepentaacetic acid

≥99% (titration)

Synonym: (Carboxymethylimino)bis(ethylenenitrilo)tetraacetic acid, N,N-Bis(2-[bis(carboxymethyl)amino]ethyl)glycine, DETAPAC, DTPA, Penta(carboxymethyl)diethylenetriamine, Pentetic acid

  • CAS Number 67-43-6

  • Linear Formula [(HOOCCH2)2NCH2CH2]2NCH2COOH

  • Molecular Weight 393.35

  •  Beilstein/REAXYS Number 1810219

  •  EC Number 200-652-8

  •  MDL number MFCD00004289

  •  PubChem Substance ID 24278381



General description

Diethylenetriaminepentaacetic acid is a diethylenetriaminepentaacetic anhydride, which is a bifunctional chelating agent. It is used for the treatment of poisoning.


Diethylenetriaminepentaacetic acid has been used:
• for cofilin activity assay
• to determine the specificity of superoxide in the transverse aortic constriction (TAC) hearts
• for Europium bead-based detection assays
• to detect reduced (S- active) or irreversibly oxidized (SO3H inactive) tyrosine-protein phosphatase non-receptor type 6 (SHP-1) in thymocytes


5, 10, 50, 100 g in glass bottle

Preparation Note


Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
Target organs 
Respiratory Tract
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
392 °F
Flash Point(C) 
200 °C


Certificate of Analysis


Certificate of Origin


Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
How can I getProduct D6518, Diethylenetriaminepentaacetic acid, to dissolve?
As is the case with other chelating agents such as EDTA and EGTA, the solubility of DTPA is a function of pH.Therefore, this compound can be solubilized with either the addition of acid such as a hydrochloric acid solution or (more likely) base such as a sodium hydroxide solution .
What are the pKa values for Product D6518, Diethylenetriaminepentaacetic acid?
The pKa values for the carboxyl groups as reported in the reference book "Data for Biochemical Research, 3rd ed., page 402, Oxford University Press, New York (1986)." are 1.8, 2.6, 4.4, 8.8, and 10.4.
What cations can be chelated with Product D6518, Diethylenetriaminepentaacetic acid(DTPA)?
DTPA forms stable complexes with most divalent and trivalent cations.Some examples are Fe3+, Cu2+, Ni2+, Pb2+, Zn2+, Fe2+, Mn2+, Ca2+,Mg2+, and Ba2+.
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