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E6383 Sigma-Aldrich

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

crystalline

Synonym: N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride, EDAC, EDC hydrochloride, EDC, WSC hydrochloride

  • CAS Number 25952-53-8

  • Empirical Formula (Hill Notation) C8H17N3 · HCl

  • Molecular Weight 191.70

  •  Beilstein/REAXYS Number 5764110

  •  EC Number 247-361-2

  •  MDL number MFCD00012503

  •  PubChem Substance ID 24894627

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Properties

Related Categories Crosslinking, Heterobifunctional Cross-Linking Reagents, Molecular Biology, Protein Modification, Protein Structural Analysis,
InChI Key   FPQQSJJWHUJYPU-UHFFFAOYSA-N
Quality Level   PREMIUM
form   crystalline
mp   110-115 °C (lit.)
solubility   H2O: ≤100 mg/mL
reaction suitability   reagent type: cross-linking reagent
reaction type: Peptide Synthesis
storage temp.   −20°C

Description

Application

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride has been used:
• for the immobilisation of trypsin onto self-assembled monolayers (SAMs)
• as a component for the preparation of collagen matrices
• for the preparation of phosphoethanolamine(PEt)-conjugated sepharose

Packaging

1, 5 g in glass bottle

Biochem/physiol Actions

Water soluble condensing reagent. EDAC is generally utilized as a carboxyl activating agent for amide bonding with primary amines. In addition, it will react with phosphate groups. EDAC has been used in peptide synthesis; crosslinking proteins to nucleic acids; and preparation of immunoconjugates as examples. Typically, EDAC is utilized in the pH range 4.0-6.0 without buffers. In particular, amine and carboxylate buffers should be avoided.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
FF2200000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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