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F7878 Supelco

Folinic acid calcium salt hydrate

analytical standard

Synonym: 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt

  • CAS Number 1492-18-8 (anhydrous)

  • Empirical Formula (Hill Notation) C20H21CaN7O7 · xH2O

  • Molecular Weight 511.50 (anhydrous basis)

  •  Beilstein/REAXYS Number 5723924

  •  PubChem Substance ID 24894951

  •  NACRES NA.24

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Properties

Related Categories Additional Drugs, Analytical Standards, Analytical/Chromatography, Biochemicals and Reagents, Coenzymes and Cofactors,
Quality Level   100
biological source   synthetic (organic)
grade   analytical standard
assay   ≥90.0%
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
color   yellow to orange
mp   240-250 °C
Featured Industry   Forensics and Toxicology
Pharmaceutical (small molecule)
format   neat
SMILES string   [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

Description

General description

Folinic acid calcium salt hydrate is a drug, widely used for the treatment of cancer, since it can reduce toxic side effects and helps to improve drug accumulation in tumor tissues.

Application

Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique. Folinic acid calcium salt hydrate may be used as an analytical reagent for the quantification of methotrexate its metabolites in biological samples using turbulent flow chromatography with tandem mass spectrometry.

Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.

Packaging

1 g in glass bottle

100, 500 mg in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Folinic Acid Enantiomers on Astec® CHIROBIOTIC® T (RP mode)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Folinic Acid Enantiomers on Astec® CHIROBIOTIC® T (RP mode)
Keywords: Antitumor agents, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Folinic Acid Enantiomers on Astec® CHIROBIOTIC® T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Folinic Acid Enantiomers on Astec® CHIROBIOTIC® T
Keywords: Antitumor agents, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

Peer-Reviewed Papers
15

References

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