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G6529 Sigma-Aldrich

L-Glutathione reduced

BioXtra, ≥98.0%

Synonym: γ-L-Glutamyl-L-cysteinyl-glycine, GSH

  • CAS Number 70-18-8

  • Linear Formula H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H

  • Molecular Weight 307.32

  •  Beilstein/REAXYS Number 1729812

  •  EC Number 200-725-4

  •  MDL number MFCD00065939

  •  PubChem Substance ID 24895261

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Properties

Related Categories Amino Acids, Antioxidant, Biochemicals and Reagents, Cell Biology, Cofactors,
InChI Key   RWSXRVCMGQZWBV-WDSKDSINSA-N
product line   BioXtra
assay   ≥98.0%
impurities   ≤0.005% Phosphorus (P)
  ≤0.1% Insoluble matter
ign. residue   ≤0.1%
mp   192-195 °C (dec.) (lit.)
solubility   H2O: 0.1 M, clear, colorless
anion traces   sulfate (SO42-): ≤0.05%
cation traces   Al: ≤0.0005%
  Ca: ≤0.0005%
  Cu: ≤0.0005%
  Fe: ≤0.0005%
  K: ≤0.005%
  Mg: ≤0.0005%
  NH4+: ≤0.05%
  Na: ≤0.005%
  Pb: ≤0.001%
  Zn: ≤0.0005%
storage temp.   2-8°C

Description

Amino Acid Sequence

γ-Glu-Cys-Gly

Packaging

1, 5, 25 g in poly bottle

Application

May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Biochem/physiol Actions

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
MC0556000

Documents

Certificate of Analysis

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Certificate of Origin

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the best way to make and store solutions of Product G6529, L-Glutathione reduced?
Reduced glutathione is soluble in water. However, aqueous solutions readily oxidize in air to oxidized glutathione, GSSG.Therefore, it is probably best to make fresh solutions for use. Half-lives of reduced glutathione in solution at various pHs and temperatures have been reported. The half-life of reduced glutathione is increased in the presence of a chelating agent. For supporting references, please consult the product information sheet (under Documents, above).
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Peer-Reviewed Papers
15

References

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