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H7753 Supelco

Hexestrol

analytical standard

Synonym: 4,4′-(1,2-Diethylethylene)diphenol, meso-3,4-Bis(4-hydroxyphenyl)hexane, Dihydrodiethylstilbestrol

  • CAS Number 84-16-2

  • Empirical Formula (Hill Notation) C18H22O2

  • Molecular Weight 270.37

  •  Beilstein/REAXYS Number 3209460

  •  EC Number 201-518-1

  •  MDL number MFCD00068996

  •  PubChem Substance ID 329815246

  •  NACRES NA.24

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Properties

Related Categories Additional Drugs, Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography,
Quality Level   100
grade   analytical standard
assay   ≥98%
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Featured Industry   Forensics and Toxicology
Pharmaceutical (small molecule)
Veterinary
format   neat
SMILES string   CC[C@H]([C@H](CC)c1ccc(O)cc1)c2ccc(O)cc2
InChI   1S/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3/t17-,18+
InChI key   PBBGSZCBWVPOOL-HDICACEKSA-N
Gene Information   human ... ESR1(2099)
rat ... Esr1(24890)

Description

General description

Hexestrol is a synthetic nonsteroidal estrogen, which can be used in human medicine as well as a growth promoter in cattle.

Application

Hexestrol may be used as a reference standard for the determination of the analyte in biological samples using immunoaffinity extraction and gas chromatography-negative-ion chemical ionization mass spectrometry.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

1, 5 g in poly bottle

Biochem/physiol Actions

The carcinogen hexestrol is a nonsteroidal synthetic estrogen. Metabolic activation of hexestrol to its quinone, which reacts with DNA to form analogous depurinating adducts, may be a primary critical event leading to oncogenic mutations and cancer initiation.

Linkage

Reduced analogue of diethylstilbestrol.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
SL0560850
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

TLC Analysis of Anabolic Compounds on HPTLC DIOL F254s (analyte set 1)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Anabolic Compounds on HPTLC DIOL F254s (analyte set 1)
Keywords: Clinical, Thin layer chromatography

Peer-Reviewed Papers
15

References

Related Products

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