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I3377 Supelco

Isoniazid

analytical standard, ≥99% (TLC)

Synonym: 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide

  • CAS Number 54-85-3

  • Empirical Formula (Hill Notation) C6H7N3O

  • Molecular Weight 137.14

  •  Beilstein/REAXYS Number 119374

  •  EC Number 200-214-6

  •  MDL number MFCD00006426

  •  PubChem Substance ID 329815370

  •  NACRES NA.24

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Properties

Related Categories A - K, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics,
Quality Level   100
grade   analytical standard
InChI Key   QRXWMOHMRWLFEY-UHFFFAOYSA-N
assay   ≥99% (TLC)
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   171-173 °C (lit.)
fluorescence   λex 360 nm; λem 450 nm (thiol adduct)
Featured Industry   Pharmaceutical (small molecule)
antibiotic activity spectrum   mycobacteria
format   neat

Description

General description

Chemical structure: pyridine

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

5, 50, 250 g in poly bottle

Biochem/physiol Actions

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
NS1751850

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

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